Angry with

MADAT

["Think of a synonym for \"furious\" followed by a preposition indicating direction."]

The clue "Angry with" leads to the answer "MADAT" through a straightforward wordplay. The term "mad" is a common synonym for "angry." The preposition "at" means "with" in the sense of being directed towards someone or something. Therefore, combining "MAD" (angry) and "AT" (with) gives you "MADAT," which fits the clue perfectly. The clue is essentially a definition for the answer, broken down into its components.