Great Lake with the most consumable 26-Down

ERIE

This lake shares its name with a canal that connects to the Hudson River.

The clue hints at Lake Erie, one of the Great Lakes, by referencing "26-Down," which is likely "water" (a common crossword answer). The phrase "most consumable" suggests Erie is the most drinkable or used for consumption, playing on its reputation for being a major source of freshwater. The wordplay ties the lake's name to the idea of something you might "consume," making it a clever but straightforward clue.