___ Paulo, Brazil

SAO

This major Brazilian city's name starts with the same three letters as "saint" in Portuguese.

This clue is looking for the first word in "São Paulo," a major city in Brazil. The blank indicates a three-letter word, and "São" is often abbreviated as "SAO" in crosswords, even though the correct spelling includes a tilde. It’s a straightforward fill-in-the-blank with a common city name.