"That's rough!"

OOF

This sound often follows a painful mistake in video games.

The clue "That's rough!" hints at the answer "OOF," which is a common internet slang expression used to react to something painful, awkward, or unfortunate. It mimics the sound of someone getting the wind knocked out of them, making it a fitting response to a rough situation. The wordplay here is straightforward, relying on the casual, expressive nature of the term.