Largest of the Dodecanese Islands

RHODES

This Greek island was once home to one of the Seven Wonders of the Ancient World.

This clue is a straightforward definition asking for the name of the biggest island in the Dodecanese chain, a group of Greek islands in the Aegean Sea. The answer is "RHODES," which is both historically significant and the largest by land area. No wordplay or tricks here—just a direct geography question.