Hip-hop's Run-___

DMC

This legendary trio’s name starts with "Run" and ends with the initials of a famous DJ.

This clue references Run-DMC, the legendary hip-hop group from the 1980s. The blank fills in the name of one of its members, DMC (Darryl McDaniels), following "Run-" as a nod to the duo’s stage names. It’s a straightforward cultural reference for fans of old-school rap, where the group’s name itself completes the clue.