The Big Apple's ___ Drive

FDR

This east-side highway shares its name with a famous Depression-era president.

"The Big Apple" is a well-known nickname for New York City, so the clue is pointing to a famous road there. "FDR Drive" is a major highway along Manhattan’s east side, named after Franklin Delano Roosevelt, the 32nd U.S. president. The answer is simply the initials "FDR," which fit neatly into the blank while referencing both the road and the historical figure.