Prima ___

DONNA

Think of a prestigious title for a leading lady in Italian opera.

"Prima ___" is an Italian phrase meaning "first lady," where the answer "DONNA" completes it—donna being Italian for "lady." The clue plays on the common musical term prima donna, which literally translates to "first lady" in opera, referring to the leading female singer. Even if you don’t know Italian, the phrase is familiar enough in English from theater and music contexts.