Allergic reaction

ITCH

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An allergic reaction often causes skin irritation, and one of the most common symptoms is an "itch." The clue plays on the direct association between allergies and that uncomfortable, scratchy sensation. Since "itch" is a short, everyday word, it fits neatly into crossword puzzles while keeping the connection obvious. No hidden wordplay—just a straightforward link between the reaction and its classic symptom.