Yoko from Tokyo

ONO

This avant-garde artist and peace activist was married to a famous Beatle and is known for her experimental music and performance art.

Yoko from Tokyo" hints at Yoko Ono, the famous Japanese artist and musician. The clue plays on her name by emphasizing "Yoko" and her association with Tokyo, Japan. The answer is simply her last name, "ONO," which fits neatly into the crossword grid.