Cosmetics-regulating org.

FDA

This U.S. agency oversees everything from food safety to drug approvals, and it also sets guidelines for ingredients in makeup and skincare products.

This clue is a straightforward abbreviation for the U.S. government agency that oversees cosmetics among other products. "Cosmetics-regulating org." points to the Food and Drug Administration, which is commonly shortened to FDA. The word "org." is shorthand for "organization," making it clear you’re looking for an agency name. No wordplay here—just a direct reference to a well-known regulatory body.