28 Across

NYT Daily • September 11, 2025

Microdosing substance

Answer:

LSD

Hint:

["This psychedelic compound, first synthesized in 1938, is often associated with tiny doses for cognitive enhancement rather than full hallucinogenic effects."]

Explanation:

"Microdosing substance" hints at a drug often taken in very small amounts for subtle effects, and LSD is a well-known psychedelic commonly used this way. The clue plays on the modern trend of microdosing—taking tiny doses of hallucinogens like LSD to boost creativity or focus without full tripping. It’s a straightforward reference since LSD is one of the most famous substances associated with this practice.

More Clues from This Puzzle

31 Across

5 letters

Simpson née Bouvier

43 Across

6 letters

Pair of words that are usually contracted

1 Down

4 letters

Semiaquatic amphibian

55 Down

4 letters

Medieval entertainer