Largest U.S. city with a majority-Hispanic population

SANANTONIO

This Texas city is home to the historic Alamo and hosts one of the biggest annual festivals celebrating Hispanic culture, Fiesta San Antonio.

This clue asks for the biggest U.S. city where over half the residents are Hispanic. San Antonio, Texas, fits perfectly—it’s the seventh-largest city in the country and has a long-standing Hispanic cultural influence, from its history as a Spanish colonial outpost to its modern-day demographics. The answer is written as one word, "SANANTONIO," which is common in crosswords to save space, even though it’s usually spelled with a space in normal writing.