Yep's opposite

NOPE

Think of a casual, two-syllable way to say "absolutely not," often used when playfully rejecting an idea.

"Yep's opposite" is a straightforward clue asking for a word that means the opposite of "yep," which is a casual way to say "yes." The answer is "NOPE," another informal term that clearly means "no." The clue plays on the contrast between these two common slang words, making it a simple but effective example of direct opposition in crossword puzzles.