53 Across

NYT Daily ? September 20, 2025

___ acid (staining agent used in electron microscopy)

Answer:

OSMIC

Hint:

This heavy metal compound, derived from osmium, is known for its sharp, pungent odor and is often used to fix and stain lipids in biological samples.

Explanation:

This clue is looking for a type of acid commonly used in electron microscopy to stain biological samples. "Osmic acid" is another name for osmium tetroxide, a chemical that binds to lipids and enhances contrast in microscopic images. The blank before "acid" signals you’re filling in the first part of the compound name, which is simply "osmic." No wordplay here—just a direct reference to a lab staple.

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General solving tip

Fill-in-the-blank clues want a set phrase or idiom. The crosses usually confirm the exact wording.

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