Valuable substance in the “Dune” universe

SPICE

This mind-altering desert resource grants extended life and enables interstellar navigation, fiercely controlled by warring factions on Arrakis.

In Dune, "spice" refers to the fictional substance melange, a highly prized drug that enables space travel and extends life. The clue plays on its central role in the story—it’s the most valuable resource in the universe, driving politics and conflict. Since "spice" is the common shorthand for melange, the answer is straightforward for fans of the books or films. No wordplay here, just a direct nod to the series’ iconic element.