University in western Pennsylvania, familiarly

PITT

This school's athletic teams are known as the Panthers and wear blue and gold.

The clue refers to the University of Pittsburgh, often called "Pitt" for short. It's a well-known university in western Pennsylvania, and "familiarly" hints that the answer is the informal nickname rather than the full name. The answer "PITT" fits the clue by using the common abbreviation.